Methyl iodide → 4-tert-Butyl-2-(methanesulfonyl)-1-methoxybenzene

HRID 543373ノート

反応式

HRID 543373 の反応式
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:13]([OH:15])=[O:14])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH2:16](N(CC)CC)C.IC>CC(C)=O>[CH3:4][C:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:6]=1)([CH3:1])[CH3:3]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 8471TriethylamineHCID 13210234HCID 13210234、化合物

生成物 1

HCID 127215654-tert-Butyl-2-(methanesulfonyl)-1-methoxybenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

17.4 g (0.076 mol) of 3-(1,1-dimethylethyl)-6-methoxybenzenesulfinic acid are suspended in 120 ml of acetone, and 13.3 ml (0.095 mol) of triethylamine and 8.5 ml (0.12 mol) of iodomethane are added. The mixture is stirred at room temperature for 2 hours and then poured onto ice-water. The precipitate which separates out is filtered off with suction and recrystallized from N-butanol.

後処理

  1. additionpoured onto ice-water
  2. filtrationThe precipitate which separates out is filtered off with suction
  3. customrecrystallized from N-butanol

出典と根拠

ORDレコード
ord-7fa0fd4a64fa42e292b09e0f1c4eef59
出典データセット
uspto-grants-1987_04
特許番号
US04661636

反応ノート

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