N-Methylol-alpha-chloroacetamide → HCID 13210257、化合物
反応式
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:6]=1)([CH3:4])[CH3:3].[Cl:16][CH2:17][C:18]([NH:20][CH2:21]O)=[O:19]>S(=O)(=O)(O)O>[Cl:16][CH2:17][C:18]([NH:20][CH2:21][C:9]1[CH:10]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[CH:6]=[C:7]([S:12]([CH3:15])(=[O:14])=[O:13])[C:8]=1[OH:11])=[O:19]参加物
4
実験手順
13.5 g (0.06 mol) of 4-(1,1-dimethylethyl)-2-methylsulfonylphenol are dissolved in 100 ml of concentrated sulfuric acid. 6.63 g (0.054 mol) of 2-chloro-N-hydroxymethylacetamide are added and the mixture is stirred at room temperature for 10 minutes. It is then poured onto ice-water and the crude product is filtered off with suction and recrystallized from toluene.
後処理
- addition