Hydrochloric Acid → N,N-Diethyl-4-phenylpiperazine-1-carboxamide--hydrogen chloride (1/1)
反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:19])[N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>C(Cl)(Cl)Cl>[ClH:20].[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:19])[N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
In 50 ml of chloroform was dissolved 2.6 g (0.01 mole) of 1-phenyl-4-diethylcarbamoylpiperazine at room temperature, and the solution was saturated with gaseous hydrogen chloride and stirred for a certain time. The solvent was removed by distillation under reduced pressure. Then, 50 ml of acetone was added to the residue and the mixture was stirred for a certain time. The precipitated crystal was recovered by filtration, washed with acetone, stirred in 50 ml of acetone to effect washing and dried to obtain 2.1 g of 1-phenyl-4-diethylcarbamoylpiperazine hydrochloride having a melting point of 190° to 192° C. The yield was 70.9%. The elementary analysis values are as follows.