反応式
[N:1]1[C:10]2[N:9]3[CH2:11][CH2:12][CH2:13][CH:8]3[C:7](=[O:14])[NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[H][H].[CH3:19][O:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[C:22]=1[CH2:23]Cl>CN(C)C=O>[CH3:30][O:29][C:25]1[CH:26]=[CH:27][CH:28]=[C:21]([O:20][CH3:19])[C:22]=1[CH2:23][N:6]1[C:5]2[CH:4]=[CH:3][CH:2]=[N:1][C:10]=2[N:9]2[CH2:11][CH2:12][CH2:13][CH:8]2[C:7]1=[O:14]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
To a stirred solution of 6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one (2.7 g. 0.01 mole) in 30 ml. of dry dimethyl formamide was added sodium hydride (0.5 g., 0.02 mole of 50% dispersion in mineral oil). When the evolution of hydrogen subsides, 2.7 g. (0.01 mole) of 2,6-dimethoxybenzyl chloride was added. The reaction mixture was stirred at room temperature for eighteen hours, and the dimethyl formamide was removed under vacuo. The residue was triturated with cold water, filtered and recrystallized from ethanol to give white crystals of the title compound, 2.7 g. (89% yield) m.p. 200°-202° C.; hydrochloride salt, m.p. 220°-223° C.
後処理
- customthe dimethyl formamide was removed under vacuo
- customThe residue was triturated with cold water
- filtrationfiltered
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-6583a93d32e343f8b31f9da4155b9909
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04446323
関連ノート
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