Hydrochloric Acid → 2-Ethoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid
反応式
[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:13]=[C:12]([NH:14]C=O)[S:11][N:10]=1)[C:6]([OH:8])=[O:7])[CH3:2].[OH-].[Na+].Cl>C(OCC)(=O)C>[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:13]=[C:12]([NH2:14])[S:11][N:10]=1)[C:6]([OH:8])=[O:7])[CH3:2]参加物
5
実験手順
A mixture of 2-ethoxyimino-2-(5-formamido-1,2,4-thiadiazol-3-yl)acetic acid (syn isomer) (4.4 g) and 1 N aqueous solution of sodium hydroxide (54 ml) was stirred for 2 hours at 50° to 55° C. The mixture was cooled in an ice bath, acidified with hydrochloric acid (5.4 ml) and extracred with ethyl acetate. The extract was dried over magnesium sulfate and evaporated to dryness. The residue was triturated with diethyl ether to give 2-ethoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid (syn isomer) (2.92 g), mp. 168° to 170° C. (dec.).
後処理
- temperatureThe mixture was cooled in an ice bath
- dry with materialThe extract was dried over magnesium sulfate
- customevaporated to dryness
- customThe residue was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-6b9a6bec9429434fb92086ca724621eb
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04447429
反応ノート
読み込み中…