Hydrazine hydrate (1:1) → 4-(3-Methoxypropyl)-3-thiosemicarbazide
反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[S:10])SC.O.[NH2:12][NH2:13]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[S:10])[NH:12][NH2:13]参加物
4
反応条件
- 温度
- 70 °C
実験手順
A solution of methyl N-(3-methoxypropyl)dithiocarbamate (100.2 g) in ethanol (300 ml) was added dropwise at 3° C. over 30 minutes to a solution of hydrazine hydrate (28 g) in ethanol (200 ml). The mixture was stirred for 4.5 hours at 70° C. The reaction mixture was concentrated and to the residue were added water and diethyl ether. The diethyl ether extract was dried over magnesium sulfate and evaporated in vacuo to give pinkish oil of 4-(3-methoxypropyl)thiosemicarbazide (89.9 g).
後処理
- concentrationThe reaction mixture was concentrated and to the residue
- additionwere added water and diethyl ether
- extractionThe diethyl ether extract
- dry with materialwas dried over magnesium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-2f3947d111d94fc5ac6e8d0a683d498a
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04447429
反応ノート
読み込み中…