Benzoyl chloride → N-benzoyl-4-hydroxypiperidine

HRID 544252ノート

反応式

HRID 544252 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[C:1]([N:14]1[CH2:15][CH2:16][CH:11]([OH:10])[CH2:12][CH2:13]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 10340Sodium CarbonateHCID 79341Piperidin-4-ol

生成物 1

HCID 9877704N-benzoyl-4-hydroxypiperidine収率 90.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
5 °C

実験手順

In this reference example, 7.03 g of benzoyl chloride was added dropwise to a mixture of 5.05 g of 4-hydroxypiperidine, 6.36 g of sodium carbonate and 60 ml of water at 10° C. with stirring. After the addition, the mixture was maintained at 5° C. for 2 hours. The reaction mixture was filtered, and then filtrate was extracted with dichloromethane. The extract was concentrated, and ether was added to crystallize, whereby 9.20 g of 1-benzoyl-4-hydroxypiperidine was obtained (yield: 90.1%).

後処理

  1. additionAfter the addition
  2. filtrationThe reaction mixture was filtered
  3. extractionfiltrate was extracted with dichloromethane
  4. concentrationThe extract was concentrated
  5. additionether was added
  6. customto crystallize

出典と根拠

ORDレコード
ord-a9b7dc2369884f3d9893afe343f82f4c
出典データセット
uspto-grants-1984_05
特許番号
US04448964

反応ノート

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