Iodoethane → 2-Ethoxynaphthalene-1-carbaldehyde

HRID 544337

反応式

HRID 544337 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13].I[CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13])[CH3:16]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 128192-Hydroxy-1-naphthaldehyde

生成物 1

HCID 880992-Ethoxynaphthalene-1-carbaldehyde

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-Hydroxy-1-naphthaldehyde (10 g., 0.058 mole) was combined with acetone (120 ml.), iodoethane (9.9 g., 0.063 mole) and anhydrous potassium carbonate (8.0 g., 0.058 mole) and the mixture heated to reflux for 48 hours. The reaction mixture was cooled to room temperature, filtered and filtrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether afforded purified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.).

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationfiltered
  4. customfiltrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether
  5. customafforded
  6. custompurified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.)

出典と根拠

ORDレコード
ord-690cd4173f8f47649acec3860e20b21f
出典データセット
uspto-grants-1984_05
特許番号
US04448971

関連ノート

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