Sodium borohydride → 2-Methylimidazo[1,2-a]pyridine-8-methanol

HRID 544474ノート

反応式

HRID 544474 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]2[CH:12]=1.[BH4-].[Na+]>C(O)(C)C>[CH3:1][C:2]1[N:3]=[C:4]2[C:9]([CH2:10][OH:11])=[CH:8][CH:7]=[CH:6][N:5]2[CH:12]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydride2 回HCID 139002412-Methylimidazo[1,2-a]pyridine-8-carbaldehyde

生成物 1

HCID 139003302-Methylimidazo[1,2-a]pyridine-8-methanol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a stirred suspension of 56.8 g (0.36 mol) 2-methyl-8-formylimidazo[1,2-a]pyridine in 400 ml isopropanol at 0°is added in portions 8 g (0.21 mol) sodium borohydride. The reaction mixture is stirred at room temperature for an additional 2 hours. The excess sodium borohydride is decomposed by the addition of distilled waterand the solution concentrated under reduced pressure at 50° C. The residue is dissolved in water and extracted with chloroform. The chloroform extracts are combined and dried over anhydrous sodium sulfate. Following filtration, the chloroform is removed under reduced pressure to give 2-methyl-8-hydroxymethylimidazo[1,2-a]pyridine.

後処理

  1. concentrationconcentrated under reduced pressure at 50° C
  2. dissolutionThe residue is dissolved in water
  3. extractionextracted with chloroform
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltration
  6. customthe chloroform is removed under reduced pressure

出典と根拠

ORDレコード
ord-0cd4031f60504719a0755472e7bc360a
出典データセット
uspto-grants-1984_05
特許番号
US04450164

反応ノート

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