Phenethyl Isothiocyanate → 1-Piperazinecarbothioamide, N-(2-phenylethyl)-4-pyrazinyl-

HRID 544483

反応式

HRID 544483 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH2:13]([N:21]=[C:22]=[S:23])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CCOCC>[CH2:13]([NH:21][C:22]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:23])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 16741Phenethyl IsothiocyanateHCID 27346391-Piperazinylpyrazine

生成物 1

HCID 34820101-Piperazinecarbothioamide, N-(2-phenylethyl)-4-pyrazinyl-

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 30 ml. of anhydrous ether is added dropwise a solution of 4.89 g. of phenethyl isothiocyanate in 30 ml. of anhydrous ether over 10 minutes. An additional30 ml. of anhydrous ether is required to maintain stirring over 30 minutes.The resulting solid is collected, dissolved in 100 ml. of benzene and 25 ml. of ethanol and cooled. The resulting solid is collected, giving 5.68 g. of the desired product as a white solid, m.p. 162°-163° C.

後処理

  1. temperatureto maintain
  2. customThe resulting solid is collected
  3. dissolutiondissolved in 100 ml
  4. temperatureof ethanol and cooled
  5. customThe resulting solid is collected
  6. customgiving 5.68 g

出典と根拠

ORDレコード
ord-442cb34a276749408afea4694e9fb418
出典データセット
uspto-grants-1984_05
特許番号
US04450272

関連ノート

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