反応式
O([C:8]([O:10][CH2:11][CH2:12][S:13][C:14]1[N:19]2[CH:20]=[CH:21][N:22]=[C:18]2[CH:17]=[CH:16][CH:15]=1)=[O:9])C1C=CC=CC=1.[NH2:23][CH2:24][CH2:25][CH2:26][OH:27]>C(Cl)(Cl)Cl>[OH:27][CH2:26][CH2:25][CH2:24][NH:23][C:8]([O:10][CH2:11][CH2:12][S:13][C:14]1[N:19]2[CH:20]=[CH:21][N:22]=[C:18]2[CH:17]=[CH:16][CH:15]=1)=[O:9]参加物
4
反応条件
- 温度
- 120 °C
実験手順
To 5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine (1.10 g, 3.50 mmoles) was added 3-aminopropanol (0.27 ml, 3.52 mmoles) and the mixture was stirred at 120° C. for 1.5 hours. The reaction mixture was cooled by standing and chloroform was added thereto, which was washed with water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 575 mg of the desired product (55.6%, colorless crystals).
後処理
- temperatureThe reaction mixture was cooled
- washwhich was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- distillationthe solvent was distilled off
- customThen, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20)
出典と根拠
- ORDレコード
- ord-349268ab472d46378b63207ed9f22d8d
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05244908
関連ノート
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