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Cyanoacetic acid → n-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-cyanoacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanoacetic acid | HCID 9740 | — |
| 反応物 | 5,6-diamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrate | HCID 12257483 | — |
| 生成物 | n-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-cyanoacetamide | HCID 225212 | — |
反応手順
5,6-Diamino-1,3-dimethyluracil hydrate is reacted with cyanoacetic acid to yield 5-cyanoacetamido-6-amino-1,3-dimethyluracil of the formula: ##STR4## The 5-cyanoacetamido-6-amino-1,3-dimethyluracil is treated with sodium hydroxide within a temperature range of 145°-155° C. to yield 8-carboxymethyltheophylline of the formula: ##STR5## The 8-carboxymethyltheophylline is treated with an alkylated inhibitor of the formula: ##STR6## to yield the compounds of formula (II).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04451652 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-bf5e700217ec4aa796a4937debfc30b6 |
| 出典メモ | uspto-grants-1984_05 |