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HRID544736

反应详情

EQUATION

反应方程式

HRID 544736 的结构方程式

REACTANTS

反应物

2
结构：N#CCC(=O)O
HCID9740

Cyanoacetic acid

C3H3NO2

结构：Cn1c(N)c(N)c(=O)n(C)c1=O.O
HCID12257483

未命名化合物

PRODUCTS

生成物

1
结构：Cn1c(N)c(NC(=O)CC#N)c(=O)n(C)c1=O
HCID225212

n-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-cyanoacetamide

C9H11N5O3

PROCEDURE

实验过程

5,6-Diamino-1,3-dimethyluracil hydrate is reacted with cyanoacetic acid to yield 5-cyanoacetamido-6-amino-1,3-dimethyluracil of the formula: ##STR4## The 5-cyanoacetamido-6-amino-1,3-dimethyluracil is treated with sodium hydroxide within a temperature range of 145°-155° C. to yield 8-carboxymethyltheophylline of the formula: ##STR5## The 8-carboxymethyltheophylline is treated with an alkylated inhibitor of the formula: ##STR6## to yield the compounds of formula (II).