Sodium borohydride → 1-(3-(Trifluoromethyl)pyridin-2-yl)ethanol
反応式
[C:1]([C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[F:13][C:10]([F:11])([F:12])[C:9]1[C:4]([CH:1]([OH:3])[CH3:2])=[N:5][CH:6]=[CH:7][CH:8]=1参加物
4
反応条件
- 温度
- -10 °C
実験手順
Dissolve 2-acetyl-3-trifluoromethylpyridine (76 g, 0.4021 moles) in anhydrous MeOH (1100 mL) and cool the resulting solution at −10° C. under N2 atmosphere. Add NaBH4 (16.0 g, 0.4238 moles) in small portions over a period of 45 minutes and stir further at −10° C. for an additional 45 minutes. Quench the reaction mixture with water (100 mL) and warm to room temperature. Concentrate the reaction mixture under vacuum, dilute with water (500 mL), extract with EtOAc (3×250 mL) and dry (MgSO4). Filter and concentrate the dried extract under vacuum to afford the title product as a yellow oil.