Bromine → 2-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide

HRID 54511

反応式

HRID 54511 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][N:5]=1)(=[O:3])[CH3:2].[Br:11]Br>Br>[BrH:11].[Br:11][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][N:5]=1)=[O:3]

参加物

4

反応物 2

HCID 24408BromineHCID 101541661-(5-Chloropyridin-2-yl)ethan-1-one

生成物 1

HCID 199594142-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒2 回

実験手順

To a solution of 10 g of 2-acetyl-5-chloropyridine in 150 ml of 48% aqueous hydrobromic acid are added 4 ml of bromine dissolved in 40 ml of hydrobromic acid, with stirring, drop by drop, at 80°. The mixture is stirred for additionally 3 hours at 80°. Afterwards the solution is evaporated in vacuo. The residue is triturated with acetone, filtered by suction, washed with acetone and dried in vacuo to yield yellow crystals of the compound, which is used for the next step without purification.

後処理

  1. customat 80°
  2. stirringThe mixture is stirred for additionally 3 hours at 80°
  3. customAfterwards the solution is evaporated in vacuo
  4. customThe residue is triturated with acetone
  5. filtrationfiltered by suction
  6. washwashed with acetone
  7. customdried in vacuo
  8. customto yield yellow crystals of the compound, which
  9. customis used for the next step without purification

出典と根拠

ORDレコード
ord-ffec2a69c7414369a7fcdc2f76a7b02f
出典データセット
uspto-grants-1997_04
特許番号
US05622982

関連ノート

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