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HRID 545120作成日：2026年10月26日

4-Chloro-3-(trifluoromethyl)benzaldehyde → (2S)-N-{[4-(4-chlorobenzyl)morpholin-2-yl]methyl}-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]acetamide

https://huagongshe.com/reaction/545120

反応式

関与物質

役割名称HCID仕込み量
反応物4-Chloro-3-(trifluoromethyl)benzaldehydeHCID 118642—
反応物(2S)-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]-N-[(morpholin-2-yl)methyl]acetamideHCID 67169399—
生成物(2S)-N-{[4-(4-chlorobenzyl)morpholin-2-yl]methyl}-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]acetamideHCID 67168675—
生成物(2S)-N-{[4-(4-chloro-3-trifluoromethylbenzyl)morpholin-2-yl]methyl}-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]acetamideHCID 67168871—

反応手順

By a similar method as in (85-1), the title compound (663 mg) was obtained as a colorless oil from the resultant product (899 mg) of (75-3) and 4-chloro-3-trifluoromethylbenzaldehyde (396 μL).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07935700B2
出典データセットuspto-grants-2011_05
ORD IDord-27bf704376c34903820ed2eb95adfcb7
出典メモuspto-grants-2011_05