Thionyl Chloride → 1-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

HRID 54514ノート

反応式

HRID 54514 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8](O)[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[N:6][CH:7]=1.S(Cl)([Cl:18])=O>C1(C)C=CC=CC=1>[Cl:18][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 199594181-(5-Chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane-1-ol

生成物 1

HCID 199594231-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1 g of 1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane-1-ol is dissolved in 2 ml of toluene, 6 ml of thionyl chloride are added and the reaction mixture is stirred for 30 minutes at room temperature. The solvent and the thionyl chloride in excess are distilled off, the residue is dissolved in 2N NaOH, extracted with ethyl acetate, dried over Na2SO4 and evaporated to yield the compound as a colourless oil.

後処理

  1. distillationThe solvent and the thionyl chloride in excess are distilled off
  2. dissolutionthe residue is dissolved in 2N NaOH
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over Na2SO4
  5. customevaporated

出典と根拠

ORDレコード
ord-3294db1eb1ce4e988dd4e58e736a0c00
出典データセット
uspto-grants-1997_04
特許番号
US05622982

反応ノート

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