Ammonium Chloride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 545250ノート

反応式

HRID 545250 の反応式
[BH4-].[Na+].[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[N:7]=1)(=[O:5])[CH3:4].[Cl-].[NH4+]>C(O)C>[Br:12][C:8]1[N:7]=[C:6]([CH:3]([OH:5])[CH3:4])[CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

生成物 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanol収率 100.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

With cooling with ice, 426 mg of sodium borohydride was added to ethanol (50 mL) solution of 4.50 g of 2-acetyl-6-bromopyridine. After stirred for 1 hour, aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, 4.58 g of the entitled compound was obtained as a colorless oily substance.

後処理

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationAfter concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0473f1e63db4488d879b1076ef22b2cb
出典データセット
uspto-grants-2011_05
特許番号
US07935708B2

反応ノート

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