Sodium Hydroxide → 3-Cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid

HRID 545345ノート

反応式

HRID 545345 の反応式
C([O:3][C:4]([C:6]1[N:7]([CH:29]2[CH2:31][CH2:30]2)[C:8]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=2)=[N:9][C:10]=1[C:11]1[CH:12]=[N:13][C:14]([OH:17])=[CH:15][CH:16]=1)=[O:5])C.[OH-].[Na+]>CCO>[CH:29]1([N:7]2[C:6]([C:4]([OH:5])=[O:3])=[C:10]([C:11]3[CH:12]=[N:13][C:14]([OH:17])=[CH:15][CH:16]=3)[N:9]=[C:8]2[C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:27])([F:28])[F:26])=[CH:20][CH:19]=2)[CH2:31][CH2:30]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178468520HCID 178468520、化合物

生成物 1

HCID 1785240453-Cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid収率 95.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 0.8 g (1.8 mmol) of 3-cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester in 3 ml of EtOH was added 0.6 ml of 6 M sodium hydroxide solution (3.8 mmol) and the mixture was heated to reflux for 16 h. The solvent was then evaporated, 1M hydrochloric acid solution was added and the resulting precipitate was isolated by filtration, affording 0.7 g (94%) of the title compound as a white solid. MS: 406.1 (MH+).

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 16 h
  3. customThe solvent was then evaporated
  4. addition1M hydrochloric acid solution was added
  5. customthe resulting precipitate was isolated by filtration

出典と根拠

ORDレコード
ord-45b47bf50a6c4deba14b42ec4a0b4789
出典データセット
uspto-grants-2011_05
特許番号
US07935707B2

反応ノート

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