Trifluoroacetic acid → 5-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

HRID 545473ノート

反応式

HRID 545473 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59556407Benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester

生成物 1

HCID 595564095-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester (3.018 g, 10.32 mmol) and TFA (20 mL) in CH2Cl2 (50 mL) was allowed to stir at rt for four days. The reaction mixture was concentrated and dried under high vacuum to give benzo[b]thiophene-2,5-dicarboxylic acid 5-methyl ester as a pale solid. MS (EI): cal'd 237.0 (MH+), exp 237.1 (MH+).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customdried under high vacuum

出典と根拠

ORDレコード
ord-d7bddac0f2f54f0c8417565910acffea
出典データセット
uspto-grants-2011_05
特許番号
US07935724B2

反応ノート

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