tert-Butyl 2-(3-nitro-1H-pyrazol-1-yl)acetate → tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate

HRID 545989ノート

反応式

HRID 545989 の反応式
[C:1]([O:5][C:6](=[O:16])[CH2:7][N:8]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[N:9]1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:16])[CH2:7][N:8]1[CH:12]=[CH:11][C:10]([NH2:13])=[N:9]1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 66712097tert-Butyl 2-(3-nitro-1H-pyrazol-1-yl)acetateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 62111572tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate収率 89%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 23938Palladium溶媒

反応条件

温度
25 °C

実験手順

To a solution containing (3-nitro-pyrazol-1-yl)-acetic acid tert-butyl ester (104 mg, 0.46 mmol) in methanol (3 mL), palladium, 10 wt. % on activated carbon, wet (˜50 mg) was added to the solution. The vial was charged with hydrogen gas (via balloon) and the mixture was stirred for 16 h at 25° C. The mixture was passed through a plug of celite and concentrated in vacuo to give the desired (3-amino-pyrazol-1-yl)-acetic acid tert-butyl ester (80 mg, 89%) as a light blue oil: ESI-LRMS m/e calcd for C9H15N3O2 [M+] 197.1, found 395.2 [2M+H+].

後処理

  1. additionwas added to the solution
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1903e2f71d2146e4b1f9d28adef04303
出典データセット
uspto-grants-2011_05
特許番号
US07935699B2

反応ノート

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