3-(3-nitro-1H-pyrazol-1-yl)propan-1-ol → 3-(3-amino-1H-pyrazol-1-yl)propan-1-ol
反応式
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][OH:12])[N:5]=1)([O-])=O>O1CCCC1.NN.[Ni]>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][OH:12])[N:5]=1参加物
5
実験手順
To a solution containing 3-(3-nitro-pyrazol-1-yl)-propan-1-ol (72 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (˜100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 3-(3-amino-pyrazol-1-yl)-propan-1-ol as a yellow oil, which was then immediately used in the next step with no further purification.
後処理
- additionwas added to the clear solution
- customafter which time the raney nickel was removed by filtration through a celite plug
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-1afc62dd100c452589fec169a08eb4d5
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07935699B2
反応ノート
読み込み中…