1-(4-methylbenzyl)-3-nitro-1H-pyrazole → HCID 571039、化合物

HRID 546030

反応式

HRID 546030 の反応式
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[N:8]2)=[CH:4][CH:3]=1>O1CCCC1.NN.[Ni]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]2)=[CH:15][CH:16]=1

参加物

5

反応物 1

HCID 70101741-(4-methylbenzyl)-3-nitro-1H-pyrazole

生成物 1

HCID 571039HCID 571039、化合物

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒2 回HCID 9321Hydrazine溶媒

実験手順

To a solution containing 1-(4-methyl-benzyl)-3-nitro-1H-pyrazole (92 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (˜100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 1-(4-methyl-benzyl)-1H-pyrazol-3-ylamine as a yellow oil which was used in the following step with no further purification.

後処理

  1. additionwas added to the clear solution
  2. customafter which time the raney nickel was removed by filtration through a celite plug
  3. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-f11207cfe36b4a66a84f0f32ba581c7f
出典データセット
uspto-grants-2011_05
特許番号
US07935699B2

関連ノート

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