Hydrogen Bromide → 5,6-Dihydro-4H-pyrrolo[3,4-d]thiazole Hydrobromide

HRID 546433ノート

反応式

HRID 546433 の反応式
C1(S([N:10]2[CH2:17][C:16]3[S:15][CH:14]=[N:13][C:12]=3[CH2:11]2)(=O)=O)C=CC=CC=1.C1(O)C=CC=CC=1.[BrH:25].C(OCC)(=O)C>O>[BrH:25].[S:15]1[C:16]2[CH2:17][NH:10][CH2:11][C:12]=2[N:13]=[CH:14]1

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 996PhenolHCID 8857Ethyl AcetateHCID 184428065-(benzenesulfonyl)-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole

生成物 1

HCID 184427795,6-Dihydro-4H-pyrrolo[3,4-d]thiazole Hydrobromide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-(benzenesulfonyl)-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole (800 mg), phenol (800 μl) and 47% hydrobromic acid (5.00 ml) was heated under reflux for 2 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and water were added to conduct liquid separation. The resultant water layer was concentrated under reduced pressure. Ethyl acetate was added to the residue, colorless powder deposited was collected by filtration to obtain the title compound (521 mg).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customliquid separation
  4. concentrationThe resultant water layer was concentrated under reduced pressure
  5. additionEthyl acetate was added to the residue, colorless powder
  6. filtrationdeposited was collected by filtration

出典と根拠

ORDレコード
ord-9d2b7fda0ab04235b69314818d1d2e51
出典データセット
uspto-grants-2011_05
特許番号
US07935824B2

反応ノート

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