1-Hydroxybenzotriazole → (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-N-[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]acrylamide

HRID 546669ノート

反応式

HRID 546669 の反応式
C(N(C(C)C)CC)(C)C.C1C=CC2N(O)N=NC=2C=1.Cl.[NH2:21][N:22]1[CH2:27][CH2:26][CH2:25][CH:24]([C:28]2[CH:33]=[C:32]([F:34])[C:31]([F:35])=[C:30]([F:36])[CH:29]=2)[C:23]1=[O:37].[CH3:38][O:39][C:40]1[CH:41]=[C:42](/[CH:52]=[CH:53]/[C:54](O)=[O:55])[CH:43]=[CH:44][C:45]=1[N:46]1[CH:50]=[C:49]([CH3:51])[N:48]=[CH:47]1.O.C(=O)(O)[O-].[Na+]>CN(C=O)C.C(OCC)(=O)C.C(Cl)CCl>[CH3:38][O:39][C:40]1[CH:41]=[C:42](/[CH:52]=[CH:53]/[C:54]([NH:21][N:22]2[CH2:27][CH2:26][CH2:25][CH:24]([C:28]3[CH:29]=[C:30]([F:36])[C:31]([F:35])=[C:32]([F:34])[CH:33]=3)[C:23]2=[O:37])=[O:55])[CH:43]=[CH:44][C:45]=1[N:46]1[CH:50]=[C:49]([CH3:51])[N:48]=[CH:47]1

参加物

9

反応物 5

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 59528030(E)-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]acrylic acidHCID 668393791-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochlorideHCID 86585896Sodium bicarbonate water

生成物 1

HCID 66839333(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-N-[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]acrylamide収率 50.6%

試薬・触媒・溶媒 3

HCID 111,2-Dichloroethane溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

IPEA (0.41 mL), HOBT (105 mg) and EDC (149 mg) were added to a solution of 1-amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride (109 mg) and (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (100 mg) in DMF (2 mL), and the reaction solution was stirred at room temperature for three hours. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate→ethyl acetate:methanol=5:1) to obtain 95 mg of the title compound. The property values of the compound are as follows.

後処理

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate→ethyl acetate:methanol=5:1)

出典と根拠

ORDレコード
ord-1c87d238d81841af8ab81ae1987d6366
出典データセット
uspto-grants-2011_05
特許番号
US07935815B2

反応ノート

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