Sodium Hydroxide → HCID 86630759、化合物

HRID 547117ノート

反応式

HRID 547117 の反応式
[OH-].[Na+:2].C[O:4][C:5](=[O:41])[C@@H:6]([NH2:40])[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([CH2:37][CH3:38])([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][CH:30]([OH:35])[C:31]([CH3:34])([CH3:33])[CH3:32])=[C:24]([CH3:36])[CH:23]=3)[CH2:20][CH3:21])=[CH:15][C:14]=2[CH3:39])=[CH:9][CH:8]=1>CO>[NH2:40][C@@H:6]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([CH2:20][CH3:21])([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][CH:30]([OH:35])[C:31]([CH3:32])([CH3:33])[CH3:34])=[C:24]([CH3:36])[CH:23]=3)[CH2:37][CH3:38])=[CH:15][C:14]=2[CH3:39])=[CH:11][CH:12]=1)[C:5]([O-:41])=[O:4].[Na+:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 57708974HCID 57708974、化合物

生成物 1

HCID 86630759HCID 86630759、化合物収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 0.5 N sodium hydroxide aqueous solution (0.064 mL) was added to a solution of (S)-amino-(4′-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2′-methyl-biphenyl-4-yl)acetic acid methyl ester (Example 166-(3); 12.0 mg, 0.0226 mmol) in methanol (0.50 mL) at room temperature, and the mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure to give the title compound (12.5 mg, 100%).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1348697cb59240198620ec076925ceba
出典データセット
uspto-grants-2011_05
特許番号
US07935688B2

反応ノート

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