Hydrochloric Acid → HCID 22478250、化合物

HRID 547176

反応式

HRID 547176 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:15])=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1.Cl>CC(O)C.CC(C)=O>[ClH:1].[Cl:15][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:21][C:20]3[CH:22]=[CH:23][C:17]([Cl:16])=[CH:18][C:19]=3[F:24])=[N:3][CH:4]=[N:5]2)=[CH:10][C:9]=1[N+:12]([O-:14])=[O:13]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 938984-Chloro-2-fluoroanilineHCID 104904554,7-Dichloro-6-nitroquinazoline

生成物 1

HCID 22478250HCID 22478250、化合物収率 90%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 3776Isopropanol溶媒

実験手順

A mixture of 4,7-dichloro-6-nitroquinazoline (24.4 g, 0.1 mol), 4-chloro-2-fluoroaniline and ethereal hydrogen chloride (100 ml of a 1M solution) in 2-propanol (600 ml) was heated at reflux for 1.5 hours. The mixture was allowed to cool and diluted with acetone. The solid product was collected by filtration, washed with acetone and dried to give 7-chloro-4-(4-chloro-2-fluoroanilino)-6nitroquinazoline hydrochloride (35.0 g, 90%) as a yellow powder.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 hours
  3. temperatureto cool
  4. filtrationThe solid product was collected by filtration
  5. washwashed with acetone
  6. customdried

出典と根拠

ORDレコード
ord-9b64e283a6044048b2a081954f550360
出典データセット
uspto-grants-2011_05
特許番号
USRE042353E1

関連ノート

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