Dimethylformamide → HCID 57669833、化合物
反応式
[CH:1]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([OH:11])=O)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:15])=O.CN(C=O)C>ClCCl>[CH:1]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([Cl:15])=[O:11])([CH3:3])[CH3:2]参加物
5
実験手順
To a solution of (S)-1-isopropylpyrrolidine-2-carboxylic acid (4 g, 23.4 mmol) in dry dichloromethane (40 mL) was added oxalyl chloride (4.4 mL, 46.8 mmol) drop wise under nitrogen at ice bath temperature (0-10° C.). After stirring for 5 min, a drop of dry DMF was added to the reaction mixture and was allowed to stir for 2 h at the same temperature. The volatiles were removed on a rotavapor at reduced pressure and the residue was allowed to stay at high vacuum pump for 1 h to afford (S)-1-isopropylpyrrolidine-2-carbonyl chloride.
後処理
- stirringto stir for 2 h at the same temperature
- customThe volatiles were removed on a rotavapor at reduced pressure
- waitto stay at high vacuum pump for 1 h
出典と根拠
- ORDレコード
- ord-4bcc616c84ab447a85cd866b0027d271
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07939513B2
反応ノート
読み込み中…