N-bromobutanimide → Ethanone, 1-[5-(bromomethyl)-6-chloro-2-pyridinyl]-

HRID 547273ノート

反応式

HRID 547273 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[CH3:11].C1C(=O)N([Br:19])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH2:11][C:3]1[CH:4]=[CH:5][C:6]([C:8](=[O:10])[CH3:9])=[N:7][C:2]=1[Cl:1]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 722140451-(6-Chloro-5-methylpyridin-2-YL)ethanone

生成物 1

HCID 86011816Ethanone, 1-[5-(bromomethyl)-6-chloro-2-pyridinyl]-

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 1-(6-chloro-5-methyl-pyridin-2-yl)-ethanone (1 eq) in CCl4 is added NBS (1 eq) and BPO (0.1 eq). The mixture is refluxed for 12 hours. After concentration, 1-(5-bromomethyl-6-chloro-pyridin-2-yl)-ethanone is isolated by flash column chromatography. MS: (ES+): 247.9 (M+1)+.

後処理

  1. temperatureThe mixture is refluxed for 12 hours
  2. concentrationAfter concentration

出典と根拠

ORDレコード
ord-40b4b35627e54876a317bd41d345991f
出典データセット
uspto-grants-2011_05
特許番号
US07939519B2

反応ノート

読み込み中…