Heptanoyl chloride → N-[4-({2-[2-(methylsulfonyl)ethoxy]ethyl}amino)quinoline-3-yl]heptanamide hydrochloride

HRID 547312ノート

反応式

HRID 547312 の反応式
[C:1]([Cl:9])(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:10][S:11]([CH2:14][CH2:15][O:16][CH2:17][CH2:18][NH:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=[CH:22][C:21]=1[NH2:30])(=[O:13])=[O:12]>C(#N)C>[ClH:9].[CH3:10][S:11]([CH2:14][CH2:15][O:16][CH2:17][CH2:18][NH:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=[CH:22][C:21]=1[NH:30][C:1](=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])(=[O:13])=[O:12]

参加物

4

反応物 2

HCID 17313Heptanoyl chlorideHCID 86064731N4-{2-[2-(methylsulfonyl)ethoxy]ethyl}quinoline-3,4-diamine

生成物 1

HCID 67203329N-[4-({2-[2-(methylsulfonyl)ethoxy]ethyl}amino)quinoline-3-yl]heptanamide hydrochloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Heptanoyl chloride (1 mL, 6.5 mmol) was added dropwise to a solution of N4-{2-[2-(methylsulfonyl)ethoxy]ethyl}quinoline-3,4-diamine (prepared as described in Parts A-E of Example 1, approximately 1.8 g, approximately 5.9 mmol) in acetonitrile (30 mL). The reaction mixture was allowed to stir for 1 hour at room temperature, then was concentrated under reduced pressure to yield N-[4-({2-[2-(methylsulfonyl)ethoxy]ethyl}amino)quinoline-3-yl]heptanamide hydrochloride as an orange foam that was used without purification.

後処理

  1. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-59cff49f07424182a3fa6e10d8f1f198
出典データセット
uspto-grants-2011_05
特許番号
US07939526B2

反応ノート

読み込み中…