Benzyl Alcohol → 3,4,4-Trifluoro-3-butenoic acid, phenylmethyl ester

HRID 54732

反応式

HRID 54732 の反応式
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](Cl)=[O:5].[CH2:10]([OH:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>ClCCl>[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([O:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:5]

参加物

4

反応物 2

HCID 244Benzyl AlcoholHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

生成物 1

HCID 152391893,4,4-Trifluoro-3-butenoic acid, phenylmethyl ester収率 92%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 3,4,4-trifluoro-3-butenoyl chloride (2.8 g, 0.0176 mole) and benzyl alcohol (0.9 g, 0.0083 mole) in 20 mL dichloromethane is heated at reflux for 40 h. The solution is cooled to room temperature, diluted with dichloromethane (15 mL), washed successively with 5% sodium bicarbonate, water and brine, and dried. Evaporation of the solvent gave 1.75 g of analytically pure product as a pale yellow oil, a 92% yield.

後処理

  1. temperatureat reflux for 40 h
  2. washwashed successively with 5% sodium bicarbonate, water and brine
  3. customdried
  4. customEvaporation of the solvent
  5. customgave 1.75 g of analytically pure product as a pale yellow oil

出典と根拠

ORDレコード
ord-33802d7b13274c35bbbf39266a33b36e
出典データセット
uspto-grants-1997_04
特許番号
US05623084

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