tert-Butyl (1S,4S)-5-(4-hydroxybenzyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate → 4-Piperidin-1-ylmethyl-phenol
反応式
[OH:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[CH2:12][C@@H:11]3[CH2:13][C@H:8]2[CH2:9]N3C(OC(C)(C)C)=O)=[CH:4][CH:3]=1>C(Cl)Cl>[N:7]1([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:22][CH:21]=2)[CH2:12][CH2:11][CH2:13][CH2:8][CH2:9]1参加物
3
実験手順
The title compound was prepared using methods analogous to those described for Intermediate 35, substituting DCE for CH2Cl2. 1H NMR (500 MHz, CDCl3): 7.14-7.03 (m, 2H), 6.75 (br s, 1H), 6.62-6.53 (m, 2H), 3.41 (s, 2H), 2.49 (s, 4H), 1.66-1.59 (m, 4H), 1.50-1.42 (m, 2H). MS (ESI): mass calcd. for C12H17NO, 191.13; m/z found, 192.20 [M+H]+.
出典と根拠
- ORDレコード
- ord-2d08a74c40b9466980c3fc8ec6b5ec6c
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07939527B2
反応ノート
読み込み中…