Aluminium lithium hydride → HCID 67197085、化合物
反応式
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:21])[CH2:12][S:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][CH:15]=2)=[CH:8][N:7]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:6]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[Br:20][C:17]1[CH:18]=[CH:19][C:14]([S:13][CH2:12][C:11]([NH:10][CH:9]2[CH2:8][N:7]([CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:6]=[C:5]2[CH2:3][OH:2])=[O:21])=[CH:15][CH:16]=1参加物
4
実験手順
150 mg (0.3 mM) of the compound obtained in Example 1 was dissolved in 2 ml of tetrahydrofuran to which 62 mg (0.9 mM) of lithium aluminum hydride was added dropwise at 0, and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 1 hour. After the reaction was terminated, the resultant was acidified with 1N hydrochloric acid solution, extracted with ethyl acetate and brine. The organic solvent layer was dried over anhydrous sodium sulfate, filtered, and then distilled under reduced pressure, to obtain 96 mg (68.1%) of the title compound.