Hydrochloric Acid → 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride

HRID 547860ノート

反応式

HRID 547860 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=2)=[CH:12][CH:11]=1.[ClH:27]>CCOC(C)=O.CCO.[Pd]>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=2)=[CH:12][CH:11]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 58287797HCID 58287797、化合物

生成物 1

HCID 671537603-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 2,4,5-trifluoro-4′-(3-nitro-benzyloxy)-biphenyl (150 mg, 0.418 mmol) and 10% Pd/C (40 mg) in EtOAc (2 mL), EtOH (10 mL) and 6N HCl (100 uL) was hydrogenated at 50 psi for 1.25 hrs. The reaction mixture was filtered through Celite and evaporated to dryness to give 3-(2′,4′,5′-trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride. LC-MS (ES) calculated for C19H14F3NO, 329.32; found m/z 330 [M+H]+.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. customevaporated to dryness

出典と根拠

ORDレコード
ord-414057368e5240a7ace24cd2a40016bf
出典データセット
uspto-grants-2011_05
特許番号
US07939569B1

反応ノート

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