1-Propanol → Propyl 4-hydroxy-3-methoxyphenylacetate

HRID 547997

反応式

HRID 547997 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][C:3]=1[O:11][CH3:12].[CH2:13]([OH:16])[CH2:14][CH3:15]>S(=O)(=O)(O)O>[CH2:13]([O:16][C:7](=[O:8])[CH2:6][C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([O:11][CH3:12])[CH:4]=1)[CH2:14][CH3:15]

参加物

4

反応物 2

HCID 10311-PropanolHCID 16928Homovanillyl alcohol

生成物 1

HCID 104310Propyl 4-hydroxy-3-methoxyphenylacetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

反応条件

温度
100 °C

実験手順

4-Hydroxy-3-methoxyphenethyl alcohol (Sigma-Aldrich) was dissolved in anhydrous 1-propanol. To this solution ˜5 drops of concentrated sulphuric acid were added and the solution was heated at 100° C. for 3-5 hours in a pressure tube. When the reaction was complete, the 1-propanol was removed under reduced pressure, the resulting oil was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution, distilled water, and then brine. The solution was dried over magnesium sulfate and filtered and the solvent was removed under reduced pressure, giving 15-A as a red oil in almost quantitative yield.

後処理

  1. customthe 1-propanol was removed under reduced pressure
  2. additionthe resulting oil was diluted with ethyl acetate
  3. washwashed with saturated sodium bicarbonate solution
  4. distillationdistilled water
  5. dry with materialThe solution was dried over magnesium sulfate
  6. filtrationfiltered
  7. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-17362f14c71142798100050de9f91d75
出典データセット
uspto-grants-2011_05
特許番号
US07939689B2

関連ノート

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