Triethylamine → Ethanamine,2-(imidazo[1,2-a]pyridin-5-ylthio)-n-methyl-

HRID 5480

反応式

HRID 5480 の反応式
CS(O[CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=O)=O.[CH2:18]([N:20](CC)CC)C.CN.CO>C(Cl)(Cl)Cl>[CH3:18][NH:20][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 233629605-[2-(Methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridineHCID 57454252Monomethylamine methanol

生成物 1

HCID 23362988Ethanamine,2-(imidazo[1,2-a]pyridin-5-ylthio)-n-methyl-収率 47.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 5-[2-(methylsulfonyloxy)etylthio]imidazo[1,2-a]pyridine (2.18 g, 8 mmoles), triethylamine (2.24 ml, 16 mmoles) and a 40% methylamine-methanol solution (20 ml) in chloroform (20 ml) was heated at reflux for 3 hours. The reaction mixture was washed with 3N NaOH and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent: methanol/chloroform (1:10)] to obtain 781 mg of the desired product (47.1%, light brown oily product).

後処理

  1. temperatureat reflux for 3 hours
  2. washThe reaction mixture was washed with 3N NaOH
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by column chromatography [eluent: methanol/chloroform (1:10)]

出典と根拠

ORDレコード
ord-7c20f62d01794f2e832a1780e09e3e32
出典データセット
uspto-grants-1993_09
特許番号
US05244908

関連ノート

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