ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Triethylamine → 4-amino-N-[3-(3,5-bis(trifluoromethyl)benzyloxy)-2-ph enylpropyl]benzamide hydrochloride

HRID 548205
ノート
印刷プレビュー

反応式

HRID 548205 の反応式
[ClH:1].[F:2][C:3]([F:27])([F:26])[C:4]1[CH:5]=[C:6]([CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1)[CH2:7][O:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:11][NH2:12].[CH2:28](N(CC)CC)[CH3:29].CCN=C=N[CH2:40][CH2:41][CH2:42][N:43](C)C.Cl.Cl.[O:48]1[CH2:53][CH2:52]OCC1>O1CCOCC1.C(Cl)Cl>[ClH:1].[NH2:43][C:42]1[CH:41]=[CH:40][C:52]([C:53]([NH:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:9][O:8][CH2:7][C:6]2[CH:5]=[C:4]([C:3]([F:26])([F:27])[F:2])[CH:21]=[C:20]([C:22]([F:24])([F:23])[F:25])[CH:19]=2)=[O:48])=[CH:29][CH:28]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 8471TriethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 204431481,4-Dioxane hydrochlorideHCID 866240403-(3,5-Bis(trifluoromethyl)benzyloxy)-2-phenylpropylamine hydrochloride

生成物 1

HCID 866240544-amino-N-[3-(3,5-bis(trifluoromethyl)benzyloxy)-2-ph enylpropyl]benzamide hydrochloride収率 65%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

Compound 67 (1.10 g, 923%) was produced as an oily product from 4-tert-butoxycarbonylaminobenzoic acid (0.57 g, 2.4 mmol), the compound produced in Example 17 (0.83 g, 2.0 mmol), triethylamine (0.28 mL, 2.0 mmol), WSC.HCl (0.46 g, 2.4 mmol) and CH2Cl2 (10 mL) according to the same manner as in Example 30. After that, Compound 67 (0.95 g, 1.6 mmol) was dissolved in dioxane (2.4 mL), 4 mol/L hydrogen chloride/dioxane (2.4 mL) was added thereto and the mixture was stirred for 20 hours at room temperature. The crystals produced after evaporation of the solvent therefrom in vacuo were filtered from petroleum ether to give Compound 61 (0.55 g, 65%).

後処理

  1. customThe crystals produced
  2. customafter evaporation of the solvent
  3. filtrationin vacuo were filtered from petroleum ether

出典と根拠

ORDレコード
ord-0c031bac82e947dd84918c547fca1f50
出典データセット
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07939552B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート