Sodium Hydroxide → 4-Chloro-3-cyclopropylmethylthio-2-methylbenzoic acid
反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[C:6]([CH3:14])[C:5]=1[S:15][CH2:16][CH:17]1[CH2:19][CH2:18]1>CO>[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[C:6]([CH3:14])[C:5]=1[S:15][CH2:16][CH:17]1[CH2:19][CH2:18]1参加物
4
実験手順
3 ml of 20% strength aqueous sodium hydroxide solution were added to 1.20 g (4.43 mmol) of methyl 4-chloro-3-cyclopropylmethylthio-2-methylbenzoate in 30 ml of methanol, and the mixture was stirred at RT for 16 h. For work-up, the mixture was concentrated on a rotary evaporator, and the residue was taken up in water. The mixture was acidified with 1M HCl, and the product was then filtered off as a solid. This gave 1.1 g of pure product.
後処理
- concentrationFor work-up, the mixture was concentrated on a rotary evaporator
- filtrationthe product was then filtered off as a solid
出典と根拠
- ORDレコード
- ord-c0c01fdc96ee49c194c26ab5ea6a0d9e
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943551B2
反応ノート
読み込み中…