Sodium Hydroxide → 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
反応式
[NH:1]1[C:5]2[N:6]=[CH:7][CH:8]=[C:9]([C:10]([O:12]C)=[O:11])[C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[NH:1]1[C:5]2[N:6]=[CH:7][CH:8]=[C:9]([C:10]([OH:12])=[O:11])[C:4]=2[CH:3]=[CH:2]1参加物
4
実験手順
A solution of 1H-pyrrolo[2,3-b]pyridine-4 carboxylic acid, methyl ester [1.8 g, Reference Example 19(c)] in methanol (60 mL) was treated with sodium hydroxide solution (25 mL, 2N) and the mixture was stirred at room temperature for 2 hours then evaporated. The residue was treated with water (50 mL) and the pH of the mixture was adjusted to 34 by addition of hydrochloric acid. The resulting yellow solid was filtered, then washed well with water and then dried to give the title compound (1.1 g) as a yellow solid.
後処理
- customthen evaporated
- additionThe residue was treated with water (50 mL)
- additionthe pH of the mixture was adjusted to 34 by addition of hydrochloric acid
- filtrationThe resulting yellow solid was filtered
- washwashed well with water
- customdried
出典と根拠
- ORDレコード
- ord-1e74e010998c4fe89144b08204b99297
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943616B2
反応ノート
読み込み中…