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Reserpine → 4-Piperazin-1-yl-thieno[3,2-c]pyridine-2-sulfonic acid (4-isopropyl-phenyl)-amide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Reserpine | HCID 5770 | — |
| 反応物 | Thienopyridine | HCID 12210218 | — |
| 反応物 | 4-Chloro-thieno[3,2-c]pyridine-2-sulfonic acid (4-isopropyl-phenyl)-amide | HCID 87290241 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Piperazin-1-yl-thieno[3,2-c]pyridine-2-sulfonic acid (4-isopropyl-phenyl)-amide hydrochloride | HCID 10343880 | — |
反応手順
4-Chloro-thieno[3,2-c]pyridine-2-sulfonic acid (4-isopropyl-phenyl)-amide (0.201 mmol, 1 equiv.) was used as the thienopyridine in Method H-L. Yield: 6.9 mg HPLC: tR=3.255 (System: 5% to 50% ACN in 3 min, C8), Purity: 95%, LC/MS: tR=1.255 (System: 30% to 60% ACN in 1.5 min, Hypersil BDS), Purity: 98%. MS: 417 (M+1). 1H NMR (270 MHz, CH3OH-d4) δ ppm 1.18 (d, J=6.86 Hz, 6H) 2.83 (m, 2H) 3.52 (m, 4H) 4.00 (m, 4H) 7.14 (m, 3H) 7.75 (d, J=6.60 Hz, 1H) 8.02 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07943639B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-491fba14137b4e7da6a8d0c8f45aaf8a |
| 出典メモ | uspto-grants-2011_05 |