Water → 2-(4-Fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

HRID 54935

反応式

HRID 54935 の反応式
[Na].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.[C:12](OCC)(=[O:19])[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1.O>C(O)C>[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:12](=[O:19])[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:10]#[N:11])=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 962WaterHCID 15291Ethyl isonicotinateHCID 68016Benzeneacetonitrile, 4-fluoro-HCID 5360545Sodium

生成物 1

HCID 141952232-(4-Fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium (2.48 g) was dissolved in dry ethanol (37 ml) under nitrogen atmosphere. To the solution was added 4-fluorophenylacetonitrile (11.65 g) and ethyl isonicotinate (16.41 ml) and the solution was refluxed for 3 hours. The reaction mixture was cooled and poured into water. The ethanol of the mixture was removed under reduced pressure. The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (16.43 g).

後処理

  1. temperaturethe solution was refluxed for 3 hours
  2. temperatureThe reaction mixture was cooled
  3. customThe ethanol of the mixture was removed under reduced pressure
  4. washThe resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid
  5. customThe separated solid was collected
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-cd938b8859464c00a385acb447f30528
出典データセット
uspto-grants-1997_04
特許番号
US05624931

関連ノート

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