Water → (2-Ethyl-pyrazolo[1,5-a]pyridin-3-yl)methanol
反応式
C([O:3][C:4]([C:6]1[C:7]([CH2:15][CH3:16])=[N:8][N:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=12)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[CH2:15]([C:7]1[C:6]([CH2:4][OH:3])=[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][N:9]2[N:8]=1)[CH3:16]参加物
5
実験手順
A solution of 2-ethyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (15 g, 68.7 mmol) in tetrahydrofuran (300 mL) was cooled in an ice bath and lithium aluminum hydride (2.6 g, 68.7 mmol) was added. The reaction mixture was stirred at room temperature for 16 h. Water was added until bubbling stopped. Silica gel was added and the solvent was evaporated in vacuo. The resulting residue was purified via silica chromatography (20-100% ethyl acetate/heptane) to yield the title compound as a yellow/brown oil (9.67 g, 80% yield).
後処理
- customuntil bubbling
- additionSilica gel was added
- customthe solvent was evaporated in vacuo
- customThe resulting residue was purified via silica chromatography (20-100% ethyl acetate/heptane)
出典と根拠
- ORDレコード
- ord-84fdd6223b6345ca9e595942a5ff6443
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943652B2
反応ノート
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