Acetic Anhydride → GlyTouCan:G72770YD

HRID 549806ノート

反応式

HRID 549806 の反応式
[N:1]([C@H:4]1[C@@H:17]([OH:18])[C@H:16]([F:19])[C@@H:15]([CH2:20][OH:21])[O:14][C@H:5]1[O:6]CC1C=CC=CC=1)=[N+]=[N-].[C:22](OC(=O)C)(=[O:24])[CH3:23].[H][H]>CO.[Pd]>[C:22]([NH:1][C@H:4]1[C@@H:17]([OH:18])[C@H:16]([F:19])[C@@H:15]([CH2:20][OH:21])[O:14][CH:5]1[OH:6])(=[O:24])[CH3:23]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 86600946benzyl 2-azido-2,4-dideoxy-4-fluoro-beta-D-mannopyranosideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 86600945GlyTouCan:G72770YD

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Compound (23) (105 mg, 0.353 mmol) was dissolved in methanol (7 ml), acetic anhydride (333 μl, 3.53 mols) was added to the solution, a catalytic amount of 10% Pd/C was thereafter added to the mixture, and the resulting mixture was stirred at room temperature after replacing the atmosphere in the reactor with hydrogen. TLC indicated disappearance of the material 2 hours later, followed by filtration with activated carbon and concentration. The residue was purified by silica gel column chromatography (ethyl acetate:methanol=5:1), giving Compound (24) (in an amount of 57 mg, 72% in yield).

後処理

  1. customdisappearance of the material 2 hours
  2. filtrationfollowed by filtration with activated carbon and concentration
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate:methanol=5:1)

出典と根拠

ORDレコード
ord-ffa34f2d87e548319f2bcb2a8a173aa0
出典データセット
uspto-grants-2011_05
特許番号
US07943763B2

反応ノート

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