2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → 1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

HRID 549953

反応式

HRID 549953 の反応式
[Br:1][C:2]1[S:6][C:5]([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[N:4][C:3]=1[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:21][C:22]1[N:26]([CH2:27][C:28](O)=[O:29])[N:25]=[C:24]([C:31]([F:34])([F:33])[F:32])[CH:23]=1>>[Br:1][C:2]1[S:6][C:5]([CH:7]2[CH2:12][CH2:11][N:10]([C:28](=[O:29])[CH2:27][N:26]3[C:22]([CH3:21])=[CH:23][C:24]([C:31]([F:34])([F:33])[F:32])=[N:25]3)[CH2:9][CH2:8]2)=[N:4][C:3]=1[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

3

反応物 2

HCID 5961182-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 671568564-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine

生成物 1

HCID 671564001-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

実験手順

4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine (II-3, 127 mg) is reacted analogously to Example I-81 with [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (118 mg). After chromatographic purification, this gives 1-{4-[5-bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (52 mg).

後処理

  1. customAfter chromatographic purification

出典と根拠

ORDレコード
ord-d75b1d47eb9449578b9109e441a24501
出典データセット
uspto-grants-2011_05
特許番号
US07943774B2

関連ノート

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