Ammonium Chloride → (4-Bromo-naphthalen-2-yl)-(5-ethylbenzo[b]-thiophen-2-yl)methanol

HRID 550248ノート

反応式

HRID 550248 の反応式
CCCCCC.C([Li])CCC.[CH2:12]([C:14]1[CH:22]=[CH:21][C:17]2[S:18][CH:19]=[CH:20][C:16]=2[CH:15]=1)[CH3:13].[Br:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[C:26]([CH:34]=[O:35])[CH:25]=1.[Cl-].[NH4+]>C1COCC1>[Br:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[C:26]([CH:34]([C:19]2[S:18][C:17]3[CH:21]=[CH:22][C:14]([CH2:12][CH3:13])=[CH:15][C:16]=3[CH:20]=2)[OH:35])[CH:25]=1

参加物

6

反応物 4

HCID 25517Ammonium ChlorideHCID 64278735-Ethylbenzo(b)thiopheneHCID 543381284-Bromonaphthalene-2-carbaldehydeHCID 178418244HCID 178418244、化合物

生成物 1

HCID 67156704(4-Bromo-naphthalen-2-yl)-(5-ethylbenzo[b]-thiophen-2-yl)methanol収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

In a nitrogen stream, an n-butyllithium hexane solution (1.6 M, 1.44 ml, 2.30 mmol) was added dropwise to a solution of 5-ethylbenzo[b]thiophene (373 mg, 2.30 mmol) in THF (15 ml) at −78° C., and the reaction solution was stirred at the same temperature for 5 minutes. To this mixture, a solution of 4-bromonaphthalene-2-carbaldehyde (515 mg, 2.19 mmol) in THF (5 ml) was added dropwise at −78° C., and the resulting mixture was stirred at the same temperature for two hours and at −20° C. for 30 minutes, and then a saturated ammonium chloride aqueous solution was added and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:9)] to obtain the title compound (780 mg, 90%).

後処理

  1. stirringthe resulting mixture was stirred at the same temperature for two hours and at −20° C. for 30 minutes
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with a saturated sodium chloride aqueous solution
  4. dry with materialdried (anhydrous magnesium sulfate)
  5. distillationthe solvent was distilled under reduced pressure
  6. customThe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:9)]

出典と根拠

ORDレコード
ord-a319a154b0984f13832477a02b75b6a9
出典データセット
uspto-grants-2011_05
特許番号
US07943748B2

反応ノート

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