1-(3-Fluorobenzyloxy)-2-methyl-4-nitrobenzene → 3-Methyl-4-[(3-fluorobenzyl)oxy]aniline
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=1[CH3:16].[H][H]>C(O)C.O=[Pt]=O>[CH3:16][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]1[CH:17]=[CH:18][CH:19]=[C:2]([F:1])[CH:3]=1)[NH2:13]参加物
5
実験手順
A mixture of 1-[(3-fluorobenzyl)oxy]-2-methyl-4-nitrobenzene (3.2 g, 12.2 mmol) and PtO2 (320 mg) in ethanol (250 ml) was stirred under an atmosphere of hydrogen (1.2 bar) until completion of the reaction (the reaction being complete when 3 mole equivalents of hydrogen have been reacted). The mixture was then filtered over celite and the solvent evaporated to give 3-methyl-4-[(3-fluorobenzyl)oxy]aniline as a yellow oil (2.83 g, 100%);
後処理
- customhave been reacted)
- filtrationThe mixture was then filtered over celite
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-9efa0effb77745d5a0f2f7e81f956d62
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07947676B2
反応ノート
読み込み中…