Water → 4-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)butanal

HRID 550532ノート

反応式

HRID 550532 の反応式
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][N:4]=[C:3]1[CH2:13][CH2:14][CH2:15][CH:16]=C.[OH2:18]>C1COCC1.O.O=[Os](=O)(=O)=O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][N:4]=[C:3]1[CH2:13][CH2:14][CH2:15][CH:16]=[O:18]

参加物

5

反応物 2

HCID 962WaterHCID 576918864-methyl-3-(4-penten-1-yl)-5-phenyl-4H-1,2,4-triazole

生成物 1

HCID 576919404-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)butanal

試薬・触媒・溶媒 2

HCID 30318Osmium Tetroxide触媒HCID 21881883Oxolane--water (1/1)溶媒

実験手順

To a solution of 4-methyl-3-(4-penten-1-yl)-5-phenyl-4H-1,2,4-triazole (196 mg, 0.86 mmol) in THF/H2O (7.5/1.5 ml) were added OsO4 (4% solution in water, 0.04 mmol) and NalO4 (2.6 mmol). The solution was stirred o.n. at r.t. Water was added and product was extract with DCM. The organic phase was separated, dried over Na2SO4 and filtered. Volatiles were evaporated in vacuo to give 178 mg of the title compound as an oil, which was used in the subsequent step without further purification.

後処理

  1. customat r.t
  2. extractionproduct was extract with DCM
  3. customThe organic phase was separated
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customVolatiles were evaporated in vacuo

出典と根拠

ORDレコード
ord-c49a722371214ade98e4657b7462a3f9
出典データセット
uspto-grants-2011_05
特許番号
US07947683B2

反応ノート

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