Acrylonitrile → Methyl 3-(2-cyano-ethylamino)-2,2-dimethylpropanoate

HRID 550596ノート

反応式

HRID 550596 の反応式
[NH2:1][CH2:2][C:3]([CH3:9])([CH3:8])[C:4]([O:6][CH3:7])=[O:5].[C:10](#[N:13])[CH:11]=[CH2:12]>CO>[C:10]([CH2:11][CH2:12][NH:1][CH2:2][C:3]([CH3:9])([CH3:8])[C:4]([O:6][CH3:7])=[O:5])#[N:13]

参加物

4

反応物 2

HCID 7855AcrylonitrileHCID 13285789Methyl 3-amino-2,2-dimethylpropanoate

生成物 1

HCID 86626329Methyl 3-(2-cyano-ethylamino)-2,2-dimethylpropanoate収率 70%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of methyl 3-amino-2,2-dimethylpropanoate (1.0 g, 7.63 mmol) and acrylonitrile (2 eq., 1 mL, 15.26 mmol) in methanol (50 mL) was stirred at room temperature for about 18 hours. After evaporation of the solvent, the residue was purified by flash chromatography on silica gel, using cyclohexane-ethyl acetate 1:1 as eluant, to give the title compound as colourless oil (0.7 g, 70% yield).

後処理

  1. customAfter evaporation of the solvent
  2. customthe residue was purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-5776beb77a7944079cfebf5714ed6082
出典データセット
uspto-grants-2011_05
特許番号
US07947686B2

反応ノート

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