4-(4-Nitrophenylthio)quinoline → 4-(4-Aminophenylthio)quinoline
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([S:10][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=2)=[CH:8][CH:9]=1参加物
4
実験手順
4-(4-nitrophenylthio)quinoline (17.0 mmoles, 4.9 g) was dissolved in 200 ml ethanol and hydrogenated over 5 g of 5% Pd/C at 40 psi for 1 hr at room temperature. The solution was filtered through celite and the solvent removed to yield 4-(4-aminophenylthio)quinoline 2.5 g, 58%. Mass spec (FD) 253. Calculated for C15H12N2S: C, 71.40; H, 4.79, N, 11.10. Found: C, 1.12; H, 4.93 N, 10.88.
後処理
- filtrationThe solution was filtered through celite
- customthe solvent removed
出典と根拠
- ORDレコード
- ord-bf218205d9a34cf88976b751baf5848d
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624937
反応ノート
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