Trifluoroacetic acid → 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

HRID 550844ノート

反応式

HRID 550844 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[CH2:15][O:16][CH3:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH3:17][O:16][CH2:15][CH:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:27])[F:25])[CH:19]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 590119454-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 866165091-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

実験手順

A mixture of 4-[2-Methoxy-1 -(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (150 mg, 0.387 mmoles) in neat trifluoroacetic acid (3 mL) was stirred at room temperature for one hour. The mixture was concentrated to dryness and pumped on high vacuum to give 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate as an oil. The material was used in the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated to dryness

出典と根拠

ORDレコード
ord-41fde793a015490e842703454f9fb29b
出典データセット
uspto-grants-2011_05
特許番号
US07947692B2

反応ノート

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